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KMID : 0948220150190030063
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Keimyung Journal of Nursing Science
2015 Volume.19 No. 3 p.63 ~ p.69
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Morphological Study : Application to Breastfeeding Nursing, Influence of Supplemental Feeding at the Early Neonatal Stage
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Yoshiko Sakuma
Kumi Arita
Ryoko Baba
Nana Kumagai
Mamoru Fujita
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Abstract
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Purpose: We investigated the effects of breast-feeding and supplementary-feeding on jejunal villi morphology and jejunal absorptive capacity at the early neonatal stage.
Methods: Newborn Wistar rats were separated from their mothers immediately after birth and allocated to a breast-fed, mixed-fed (breast-feeding and formula-feeding), or formula-fed group. Rats were fed accordingly for 3 days. We then investigated the morphology of jejunal villi and the mechanism of macromolecular uptake by absorptive cells in each group. Horseradish peroxidase (HRP) was used as a representative macromolecule.
Results: After three days of feeding, jejunal villi of breast-fed rats were longest, followed by the mixed-fed, and then formula-fed groups. Additionally, HRP underwent transcytosis from the apical membrane to the basolateral membrane of absorptive cells in the breast-fed group. HRP did not undergo transcytosis in either the formula-fed or mixed-fed rat jejuna.
Conclusion: Our findings suggest that supplementary feeding affects normal villus development and impairs endocytosis and transcytosis in early neonatal stage jejunal absorptive cells.
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KEYWORD
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Breastfeeding , Newborn , Jejunum , Transcytosis
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